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The Centre carries out frontline research & development in the broad areas of
bioinformatics, structural biology and structural pharmacology.
Some of the projects in progress include,
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Structural analysis of a thermostable xylanase
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Peptide structure analysis
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Structural studies on lectins
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Structural analysis of drug binding to dopamine receptors
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Protein side chain conformation analysis
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Structural studies on Phospholipase A2 mutants
Development
Protein Sequence Search Tool (PSST- 1.0)
A web-based search tool, PSST has been developed to retrieve
the user input query from the single letter amino acid code input file
"pdb_seqres.txt", obtained from the Protein Data Bank. The search
tool consists of the following four modules:
Depending upon the search category, the search tool will search the
protein sequence database (updated every week from the Protein Data Bank
, USA) resided in our Bioinformatics Server and will display the related
search results to the client browser. Further, developmental work
on this search tool is in progress.
The URL address is : http://pranag.physics.iisc.ernet.in/psst
Genome ftp server
The area of genomics has taken off in full swing in the years
and several genome sequences are now available in the entirety. We
have therefore, recently setup a manual FTP (File Transfer Protocol) server
on a PC platform in the bioinformatics centre of the complete genome sequences
from several organisms available in Entrez.
The URL address is :
http://pranag.physics.iisc.ernet.in
Sequences can be downloaded from
ftp://pranag.physics.iisc.ernet.in/Pub/genome
Login: anonymous and password is your full e-mail id.
A README fileis included which explains the complete contents
of the server and file location.
PDB
ftp server
Several research groups in the institute and elsewhere in the
region have projects involving database analysis. We have therefore
initiated an effort to create a manual FTP server in our centre.
The complete atomic coordinates of the three dimensional protein structures
deposited in the Protein Data Bank will be made available through this
server.
The URL address is :
http://iris.physics.iisc.ernet.in
Entries can be downloaded from
ftp://iris.physics.iisc.ernet.in/pub/genome
Login: anonymous and password is your full e-mail id.
A complete list of all PDB entries is available at
http://iris.physics.iisc.ernet.in/entries.txt
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