Bioinformatics Centre
(Centre of Excellence in Structural Biology and Bio-Computing)

Interactive Graphics Based Molecular Modelling Facility
Indian Institute of Science
Bangalore - 560012

 
 
Training

One of the major thrusts of our Centre has been to provide training to students, teachers and research workers in the field of biology in Bioinformatics.  For this purpose various activities have been organised. IISc. Course

Current Year (2003) Courses Offered:


SE 301 (AUG) 2:0
Bioinformatics by
S. RAMAKUMAR AND K. SEKAR

Syllabus:

Biological Databases: Organisation, searching and retrieval of information, accessing global bioinformatics resources using internet links. Introduction to Unix operating system and network communication. Nucleic Acids Sequence assembly, restriction mapping, finding simple sites and transcriptional signals, coding region identification, RNA secondary structure prediction. Similarity and Homology, dotmatrix methods, dynamic programming methods, scoring systems, multiple sequence alignments, evolutionary relationships, genome analysis. Protein Physical properties, structural properties - secondary structure prediction, hydrophobicity patterns, detection of motifs, structural database (PDB). Genome databases, Cambridge structure database, data mining tools and techniques, Structural Bioinformatics, Topics from the current literature will be discussed. Hands on experience will be provided.


SE 302 (JAN) 2:0
Computational Approaches to Drug Discovery
          by
NAGASUMA CHANDRA

Syllabus:

Introduction to the process of drug and vaccine discovery, Principles of drug action, Drug and target structures, Brief introduction to systems biology, pharmacology and chemoinformatics, Use of genomics and proteomics for understanding diseases at the molecular level, Sequence-structure-function relationship in proteins, Strategies for target identification and validation, protein structure prediction, Molecular modeling protein-ligand interactions, Structure-based ligand design, Lead identification, design and lead optimization, Challenges in drug and vaccine discovery, Relevant algorithms and topics from current literature.


Previous courses

Bioinformatics Course for the year 1999
ANALYSIS OF NUCLEIC ACID, PROTEIN SEQUENCES AND STRUCTURES
A sample assignment for the Protein Bioinformatics course of 1999 batch.
Best student assignment for the Protein Bioinformatics part.


* Symposium & Workshop on Current trends in Bioinformatics
        March 27th to 29th, 2001, IISc Bangalore
 
Workshop

The Centre conducts workshops and training programmes regularly in areas related to Bioinformatics.  As a part of this activity, the centre conducted a workshop on the application of "Bioinformatics in Drug Discovery"  from 22nd to 24th of March 2000.

Other Training Programmes

As part of the course, "Application of computers in Biotechnology" training (lectures and hands-on) was provided to the postgraduate students of Biotechnology, University of Agricultural Sciences, GKVK, Bangalore.  We also provide training to people from other Distributed Information Centres (DIC) and various sub-DICs across the country.